Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor.

Title:

Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor.

Dataset

identifier:	1772082
description:	epitope description:VVRF antigen name:Coagulation factor VIII host organism:Mus musculus BALB/c antibody name:F7B4
aggregation:	instance of dataset
availability:	available
primaryPublications:	12958606

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017978
landingPage:	http://www.iedb.org/assay/1772082

Publication

type:	Literature
publicationVenue:	Thromb Haemost
dates:	2003

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Sanjeev Raut Sylvie Villard Sabrina Grailly Jean-Guy G Gilles Claude Granier Jean-Marie R Saint-Remy Trevor W Barrowcliffe

Data Type

method:	antigen inhibition

Study

name:	Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor.
description:	The epitope-containing fragment (LTDSEMDVVRFD) inhibited the epitope specific mAb binding to FVIII in ELISA.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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