Development of recombinant vaccines against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation in murine colitis.

Title:

Development of recombinant vaccines against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation in murine colitis.

Dataset

identifier:	1772070
description:	epitope description:TPDAPGETV antigen name:Interleukin-12 subunit beta host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	19786142

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017648
landingPage:	http://www.iedb.org/assay/1772070

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2009

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Qingdong Guan Yanbing Ma China-Li Hillman Allan Ma Gang Zhou Gefei Qing Zhikang Peng

Data Type

method:	biological activity

Study

name:	Development of recombinant vaccines against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation in murine colitis.
description:	The antiserum of epitope-vaccine immunized animals was able to inhibit IL-12-induced IFN-gamma secretion of splenocytes in a dose dependent manner.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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