Structural characterization and optimization of antibody-selected phage library mimotopes of an antigen associated with autoimmune recurrent thrombosis.

Title:

Structural characterization and optimization of antibody-selected phage library mimotopes of an antigen associated with autoimmune recurrent thrombosis.

Dataset

identifier:	1772673
description:	epitope description:AGPCILLARDRCPG host organism:Homo sapiens Caucasian antibody name:ACA 6501
aggregation:	instance of dataset
availability:	available
primaryPublications:	9819200

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017550
landingPage:	http://www.iedb.org/assay/1772673

Publication

type:	Literature
publicationVenue:	Biochemistry
dates:	1998

Dimension

study type:	b cell assays
subject species:

Person

fullName:	D S Sem B L Baker E J Victoria D S Jones D Marquis L Yu J Parks S M Coutts

Data Type

method:	antigen inhibition

Study

name:	Structural characterization and optimization of antibody-selected phage library mimotopes of an antigen associated with autoimmune recurrent thrombosis.
description:	The epitope was identified by phage display and confirmed by fluorescence polarization. Replacement of R9 with proline significantly decreased affinity to the ACA. The K_D was measured in nM.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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