Identification of the binding site for an alloantibody to von Willebrand factor which inhibits binding to glycoprotein Ib within the amino-terminal region flanking the A1 domain.

Title:

Identification of the binding site for an alloantibody to von Willebrand factor which inhibits binding to glycoprotein Ib within the amino-terminal region flanking the A1 domain.

Dataset

identifier:	1772989
description:	epitope description:HCQICHCDVVNLTCE antigen name:von Willebrand factor host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10365755

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017983
landingPage:	http://www.iedb.org/assay/1772989

Publication

type:	Literature
publicationVenue:	Thromb Haemost
dates:	1999

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	M Shibata M Shima Y Fujimura Y Takahashi H Nakai Y Sakurai M Asatani A Nomura H J C Giddings A Yoshioka

Data Type

method:	antigen inhibition

Study

name:	Identification of the binding site for an alloantibody to von Willebrand factor which inhibits binding to glycoprotein Ib within the amino-terminal region flanking the A1 domain.
description:	The epitope was able to compete for binding of the patient's antibody to 52/48K fragment of von Willebrand factor in a dot blot. The patient's antibody was mainly IgG4 and IgG2. The epitope was also able to neutralize the F(ab')2 antibody's inhibition of high shear stress-induced platelet aggregation (SIPA),

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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