Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies.

Dataset

identifier:	1773320
description:	epitope description:NPVENMMDRDSQ host organism:Homo sapiens antibody name:Patient sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	19533722

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1016484
landingPage:	http://www.iedb.org/assay/1773320

Publication

type:	Literature
publicationVenue:	ChemMedChem
dates:	2009

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Christoph Kessel Wolfhart Kreuz Katharina Klich Karin Becker-Peters Frank Vorpahl Ursula Dietrich Thomas Klingebiel Christoph Kö nigs

Data Type

method:	antigen inhibition

Study

name:	Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies.
description:	The synthetic peptide C6 representing a mimotope of an epitope on the FVIII A2 domain and isolated with plasma from a hemophilia A patient blocked binding of anti-FVIII antibodies from patients’ plasma to immobilized FVIII in a concentration-dependent manner. A control peptide C6A, which is homologous to C6 except for four N-terminal amino acids, decreased IgG binding to immobilized FVIII by 40%. The addition of heterologous mimotopes increased inhibition.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.