Crystal structure of human prion protein bound to a therapeutic antibody. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Crystal structure of human prion protein bound to a therapeutic antibody.

Dataset

identifier:	1773336
description:	epitope description:S143, D144, Y145, R148 R151, E152, K204 antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:ICSM 18
aggregation:	instance of dataset
availability:	available
primaryPublications:	19204296

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019675
landingPage:	http://www.iedb.org/assay/1773336

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2009

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	S V Antonyuk C R Trevitt R W Strange G S Jackson D Sangar M Batchelor S Cooper C Fraser S Jones T Georgiou A Khalili-Shirazi A R Clarke S S Hasnain J Collinge

Data Type

method:	biological activity

Study

name:	Crystal structure of human prion protein bound to a therapeutic antibody.
description:	Epitope-specific mAb ICSM 18 inhibited prion propagation in prion-infected ScN2a neuroblastoma cells with an estimated IC50 value of 7.5 X 10 ^-10 M. Prion propagation was measured as the levels of proteinase K-resistant PrP.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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