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Title: In vivo induction of tolerance by an Ig peptide is not affected by the deletion of FcR or a mutated IgG Fc fragment.
identifier: 1774308
description:
epitope description:LEDARRLKAIYEKKK
antigen name:Other Escherichia coli protein
host organism:Mus musculus BALB/c
aggregation:
instance of dataset
availability:
available
primaryPublications: 12096035
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1010182
landingPage: http://www.iedb.org/assay/1774308
type:
Literature
publicationVenue:
Int Immunol
dates:
2002
study type: b cell assays
subject species: Escherichia coli
fullName:
Moustapha el-Amine
Jennifer A Hinshaw
David W Scott
method:
in vivo assay
name:
In vivo induction of tolerance by an Ig peptide is not affected by the deletion of FcR or a mutated IgG Fc fragment.
description:
Mice receiving epitope-transduced B cell transfer showed in vivo induction of tolerance. Tolerance was demonstrated by reduced epitope-specific IgG titer in an ELISA compared with recipients of OVA-transduced B cells. Transfer of epitope-transduced B cells from BALB/c and FcgammaRII-/- donors caused the same outcome in BALB/c or FcgammaRII-/- recipients, indicating that FcgammaRII deletion had no effect on induction of humoral tolerance.

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