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Title: Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.
identifier: 1776860
description:
epitope description:K73, D83, N146, L150, Q153, H154, R157, K159, R161
antigen name:Thrombopoietin
host organism:Mus musculus BALB/c
antibody name:mAb 1653
aggregation:
instance of dataset
availability:
available
primaryPublications: 9252374
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1009620
landingPage: http://www.iedb.org/assay/1776860
type:
Literature
publicationVenue:
J Biol Chem
dates:
1997
study type: b cell assays
subject species: Homo sapiens
fullName:
K H Pearce Jr
B J Potts
L G Presta
L N Bald
B M Fendly
J A Wells
method:
ELISA
name:
Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.
description:
The epitope was defined by loss of binding by mutagenesis of TPO.
The monoclonal antibody did not bind to TPO when the epitope residues were individually subsituted with alanine.

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