Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab.

Title:

Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab.

Dataset

identifier:	1775731
description:	epitope description:ERIYHFV antigen name:Interleukin-2 receptor subunit alpha host organism:Mus musculus BALB/c antibody name:basiliximab
aggregation:	instance of dataset
availability:	available
primaryPublications:	17440057

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017606
landingPage:	http://www.iedb.org/assay/1775731

Publication

type:	Literature
publicationVenue:	Cancer Res
dates:	2007

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Mascha Binder Friederike-Nora Vö gtle Stefan Michelfelder Fabian Mü ller Gerald Illerhaus Sangeeth Sundararajan Roland Mertelsmann Martin Trepel

Data Type

method:	immuno staining

Study

name:	Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab.
description:	The epitope-specific mAb bound to CD25 whne it ws transfected inot 293T cells. The critical amino acids, 4Y, 5H, and 6F were determined based on lack of binding upon mutation.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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