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Title: Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis.
identifier: 1775957
description:
epitope description:IEIGLEGKGFEPTLEALFGK
antigen name:Apolipoprotein B-100
host organism:Homo sapiens
antibody name:IEI-A8, IEI-G8, IEI-E3, IEI-D8
aggregation:
instance of dataset
availability:
available
primaryPublications: 15451805
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1017428
landingPage: http://www.iedb.org/assay/1775957
type:
Literature
publicationVenue:
Circulation
dates:
2004
study type: b cell assays
subject species: Homo sapiens
fullName:
Alexandru Schiopu
Jenny Bengtsson
Ingrid Sö
derberg
Sabina Janciauskiene
Stefan Lindgren
Mikko P S Ares
Prediman K Shah
Roland Carlsson
Jan Nilsson
Gunilla Nordin Fredrikson
method:
surface plasmon resonance (SPR)
name:
Recombinant human antibodies against aldehyde-modified apolipoprotein B-100 peptide sequences inhibit atherosclerosis.
description:
The epitope sequence was 2 malondialdehyde (MDA)-modified, which forms covalent adducts with lysine and histidine residues.
The epitope-specific antibody clones were tested for binding to 2 malondialdehyde (MDA)-modified apoB-100, with a range for KD values of 10 to 3. Binding was also detected by ELISA. Binding to MDA-modified but not unmodified human LDL was also seen.

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