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Title: An immunodominant epitope on DNA topoisomerase I is conformational in nature: heterogeneity in its recognition by systemic sclerosis sera.
identifier: 1777171
description:
epitope description:PVEKRVFKNLQLFMENKQPEDDL
antigen name:DNA topoisomerase 1
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 10366110
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1017543
landingPage: http://www.iedb.org/assay/1777171
type:
Literature
publicationVenue:
Arthritis Rheum
dates:
1999
study type: b cell assays
subject species: Homo sapiens
fullName:
M Kuwana
J Kaburaki
T A Medsger Jr
T M Wright
method:
antigen inhibition
name:
An immunodominant epitope on DNA topoisomerase I is conformational in nature: heterogeneity in its recognition by systemic sclerosis sera.
description:
The epitope conjugated to BSA or KLH did not compete with a recombinant topo I protein for binding by sera from SSc patients. Similar results were observed in direct ELISA. Cys and tyr residues were added to the N-terminus to facilitate conjugation.

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