Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice.

Title:

Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice.

Dataset

identifier:	1777565
description:	epitope description:NANNGNLLLRNKKVT antigen name:Lupus La protein homolog host organism:Mus musculus A/J
aggregation:	instance of dataset
availability:	available
primaryPublications:	8920873

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019729
landingPage:	http://www.iedb.org/assay/1777565

Publication

type:	Literature
publicationVenue:	J Exp Med
dates:	1996

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	P Reynolds T P Gordon A W Purcell D C Jackson J McCluskey

Data Type

method:	western blot

Study

name:	Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self-antigen La (SS-B) permits induction of systemic autoimmunity in normal mice.
description:	Immunization with the epitope did not cause intramolecular spreading of autoimmunity to the mLa 346-415 fragment.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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