Identification of a dominant epitope in the hemagglutinin of an Asian highly pathogenic avian influenza H5N1 clade 1 virus by selection of escape mutants.

Title:

Identification of a dominant epitope in the hemagglutinin of an Asian highly pathogenic avian influenza H5N1 clade 1 virus by selection of escape mutants.

Dataset

identifier:	1781133
description:	epitope description:K205 antigen name:Hemagglutinin host organism:Mus musculus BALB/c antibody name:8C5, 5A1
aggregation:	instance of dataset
availability:	available
primaryPublications:	20521695

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019783
landingPage:	http://www.iedb.org/assay/1781133

Publication

type:	Literature
publicationVenue:	Avian Dis
dates:	2010

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/crested eagle/Belgium/01/2004(H5N1))

Person

fullName:	Helena Lage Ferreira Bé né dicte Lambrecht Steven van Borm Lea Torrieri-Dramard David Klatzmann Bertrand Bellier Thierry van den Berg

Data Type

method:	biological activity

Study

name:	Identification of a dominant epitope in the hemagglutinin of an Asian highly pathogenic avian influenza H5N1 clade 1 virus by selection of escape mutants.
description:	The epitope was defined by the loss of hemagglutination inhibition and virus neutralization activities by monoclonal antibodies in mutant viruses grown in the presence of the neutralizing antibodies. The epitope specific monoclonal antibodies neutralized the virus in vitro. Viruses mutated at K189 (K205) were not neutralized by the monoclonal antibodies.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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