Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp1663-Ser1669.

Title:

Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp1663-Ser1669.

identifier:	1781546
description:	epitope description:DDTIS antigen name:Coagulation factor VIII host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	2455712

study type:	b cell assays
subject species:	Homo sapiens

fullName:	M Shima C A Fulcher S de Graaf Mahoney R A Houghten T S Zimmerman

method:	cross blocking

name:	Localization of the binding site for a factor VIII activity neutralizing antibody to amino acid residues Asp1663-Ser1669.
description:	Anti-J31B peptide mAb binding to Factor VIII and its inhibition of the procoagulant activity of Factor VII was blocked with J31B peptide. The mAb was shown to be epitopes-specific, which was defined by single residue deletions and substitutions of J31B in the ability to block binding and inhibitory activity.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.