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Title: Recombinant TCR ligand reverses clinical signs and CNS damage of EAE induced by recombinant human MOG.
identifier: 1779990
description:
epitope description:MEVGWYRPPFSRVVHLYRNGK
antigen name:Myelin-oligodendrocyte glycoprotein (UniProt:Q16653)
host organism:Mus musculus C57BL/6
aggregation:
instance of dataset
availability:
available
primaryPublications: 19789980
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1019969
landingPage: http://www.iedb.org/assay/1779990
type:
Literature
publicationVenue:
J Neuroimmune Pharmacol
dates:
2010
study type: b cell assays
subject species: Homo sapiens
fullName:
Sushmita Sinha
Sandhya Subramanian
Ashley Emerson-Webber
Maren Lindner
Gregory G Burrows
Marjorie Grafe
Christopher Linington
Arthur A Vandenbark
Claude C A Bernard
Halina Offner
method:
antigen inhibition
name:
Recombinant TCR ligand reverses clinical signs and CNS damage of EAE induced by recombinant human MOG.
description:
The epitope sequence was cited in the reference Chou et al., J Neurosci Res. 2004 Sep 1
77(5):670-80 [PMID: 15352213].
Epitope pre-adsorption of sera from mice immunized with the epitope completely abrogated detection of rhMOG-reactive antibodies by ELISA. Ig kappa, IgG1 and IgG2b Ab showed similar results.

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