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Title: In silico prediction of FVIII epitopes recognised by natural autoantibodies in polyvalent immunoglobulin concentrates.
identifier: 1779863
description:
epitope description:SEGAEYDDQTSQREKEDDK
antigen name:Coagulation factor VIII
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 17113150
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1017104
landingPage: http://www.iedb.org/assay/1779863
type:
Literature
publicationVenue:
Mol Immunol
dates:
2007
study type: b cell assays
subject species: Homo sapiens
fullName:
Mario Di Giambattista
Theo Branckaert
Vincent Hougardy
Geoffrey Kemball-Cook
Ruth Laub
method:
biological activity
name:
In silico prediction of FVIII epitopes recognised by natural autoantibodies in polyvalent immunoglobulin concentrates.
description:
The epitope sequence is from the cited reference, Vehar et al. Nature 312, 337&ndash
342 (1984) [PMID 6438527].
The anti-epitope Igs were purified by affinity chromatography to the epitope, and the mono-specific IgG fraction was tested for its inhibition of purified factor VIII clotting activity on hemophilia serum samples.

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