Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III.

Title:

Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III.

identifier:	1781948
description:	epitope description:T330 antigen name:Genome polyprotein host organism:Mus musculus antibody name:7H2, 5H10, C5C
aggregation:	instance of dataset
availability:	available
primaryPublications:	20447672

study type:	b cell assays
subject species:	West Nile virus NY-99

fullName:	Shuliu Zhang Evgeniy I Bovshik Rodrigo Maillard Gregory D Gromowski David E Volk Catherine H Schein Claire Y-H Huang David G Gorenstein James C Lee Alan D T Barrett David W C Beasley

method:	biological activity

name:	Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III.
description:	The epitope-specific mAbs neutralized the virus as determined by a reduction in virus titer. Substitution of the epitopic residue with alanine (T330A, but not with isoleucine (T330I), caused a reduction in virus titer.

name:	iedb
homePage:	http://www.iedb.org

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