Conformation-dependent high-affinity monoclonal antibodies to prion proteins. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Conformation-dependent high-affinity monoclonal antibodies to prion proteins.

Dataset

identifier:	1782347
description:	epitope description:SQWN antigen name:Major prion protein host organism:Mus musculus FVB/N Prp null antibody name:F20-89a
aggregation:	instance of dataset
availability:	available
primaryPublications:	20530267

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019823
landingPage:	http://www.iedb.org/assay/1782347

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Larry H Stanker Ana V Serban Elisa Cleveland Robert Hnasko Azucena Lemus Jiri Safar Stephen J DeArmond Stanley B Prusiner

Data Type

method:	western blot

Study

name:	Conformation-dependent high-affinity monoclonal antibodies to prion proteins.
description:	Brain homogenate from a sheep with scrapie was subjected to PK digestion. Both digested and undigested samples were recognized by the epitope-specific mAb, suggesting it recognizes both PrPC also bound to the denatured, PK-resistant PrPSc isoform (rPrPSc), also called PrP 27-30.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.