A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.

Dataset

identifier:	1782371
description:	epitope description:L33, G34, Y38, A94, C95, H96, L97, A108, D109, A112, C113, K115, R116, R119 antigen name:Lysozyme C host organism:Camelus dromedarius antibody name:cAb-HuL6
aggregation:	instance of dataset
availability:	available
primaryPublications:	12917687

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019481
landingPage:	http://www.iedb.org/assay/1782371

Publication

type:	Literature
publicationVenue:	Nature
dates:	2003

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Mireille Dumoulin Alexander M Last Aline Desmyter Klaas Decanniere Denis Canet Gö ran Larsson Andrew Spencer David B Archer Jurgen Sasse Serge Muyldermans Lode Wyns Christina Redfield André Matagne Carol V Robinson Christopher M Dobson

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.
description:	The dissociation constants for the binding of epitope specific cAb-HuL6 to wild type lysozyme (KD = 0.7 nM) and the amyloidogenic variant D67H lysozyme (KD = 1.2 nM) were similar.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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