The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis.

Title:

The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis.

Dataset

identifier:	1784360
description:	epitope description:PKPEQ antigen name:UniProt:Q97T39 host organism:Mus musculus CBA antibody name:PR-5C4.7
aggregation:	instance of dataset
availability:	available
primaryPublications:	20194601

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019816
landingPage:	http://www.iedb.org/assay/1784360

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2010

Dimension

study type:	b cell assays
subject species:	Streptococcus pneumoniae

Person

fullName:	Calvin C Daniels Patricia Coan Janice King Joanetha Hale Kimberly A Benton David E Briles Susan K Hollingshead

Data Type

method:	flow cytometry

Study

name:	The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis.
description:	Some S. Pneumoniae strains such as D39 do not contain the epitope sequence. The epitope-specific mAb stained the surface of whole bacteria expressing the epitope sequence, implying that the epitope is surface exposed.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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