The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis.

Title:

The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis.

Dataset

identifier:	1784357
description:	epitope description:EKSADQQAEEDYARRSEEEYNRLTQQQ antigen name:UniProt:Q97T39 host organism:Mus musculus CBA
aggregation:	instance of dataset
availability:	available
primaryPublications:	20194601

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019816
landingPage:	http://www.iedb.org/assay/1784357

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	2010

Dimension

study type:	b cell assays
subject species:	Streptococcus pneumoniae

Person

fullName:	Calvin C Daniels Patricia Coan Janice King Joanetha Hale Kimberly A Benton David E Briles Susan K Hollingshead

Data Type

method:	in vivo assay

Study

name:	The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsis.
description:	Immunization with the epitope provided some protection upon challenge with S. pneumoniae 3JYP2670 (carrying the epitope sequence with subsitutions at positions 1 to 4). Also, antibodies from immunized mice stained the surface of the whole bacteria in FACS, confirming that the epitope is surface exposed, and the antibody levels staining the surface of whole bacteria in the sera of the immunized mice that subsequently survived the challenge was higher than in those that became moribund.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.