Characterization of a monoclonal antibody directed against the carboxyl-terminus of human factor XIII. An epitope exposed upon denaturation and conserved across species lines.

Title:

Characterization of a monoclonal antibody directed against the carboxyl-terminus of human factor XIII. An epitope exposed upon denaturation and conserved across species lines.

Dataset

identifier:	1784459
description:	epitope description:QIQRRPSM antigen name:Coagulation factor XIII A chain host organism:Mus musculus BALB/c antibody name:7A4
aggregation:	instance of dataset
availability:	available
primaryPublications:	7513094

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020700
landingPage:	http://www.iedb.org/assay/1784459

Publication

type:	Literature
publicationVenue:	Thromb Haemost
dates:	1994

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Y Song S M Taubenfeld D Sheng G R Matsueda

Data Type

method:	antigen inhibition

Study

name:	Characterization of a monoclonal antibody directed against the carboxyl-terminus of human factor XIII. An epitope exposed upon denaturation and conserved across species lines.
description:	An extra N-terminus cysteine was added to the epitope used for immunization. The epitope inhibited the binding of epitope-specific mAb to factor XIII. Deletion study showed that residue M8 of the epitope was the single most important amino acid for mAb recognition.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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