Mutations within a conserved region of the hepatitis C virus E2 glycoprotein that influence virus-receptor interactions and sensitivity to neutralizing antibodies.

Title:

Mutations within a conserved region of the hepatitis C virus E2 glycoprotein that influence virus-receptor interactions and sensitivity to neutralizing antibodies.

Dataset

identifier:	1784484
description:	epitope description:N415, N417, G418 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:AP33
aggregation:	instance of dataset
availability:	available
primaryPublications:	20237087

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019761
landingPage:	http://www.iedb.org/assay/1784484

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2010

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus JFH-1

Person

fullName:	Simrat Dhillon Jeroen Witteveldt Derek Gatherer Ania M Owsianka Mirjam B Zeisel Muhammad N Zahid Malgorzata Rychłowska Steven K H Foung Thomas F Baumert Allan G N Angus Arvind H Patel

Data Type

method:	biological activity

Study

name:	Mutations within a conserved region of the hepatitis C virus E2 glycoprotein that influence virus-receptor interactions and sensitivity to neutralizing antibodies.
description:	Another mAb, 3/11, obtained in rat, also recognized the same residues as mAb AP33. The substitution of the epitope residues (N415D, N417S and G418D) abolished neutralization of the individual mutation-carrying HCV viruses.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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