Prions of ruminants show distinct splenotropisms in an ovine transgenic mouse model. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Prions of ruminants show distinct splenotropisms in an ovine transgenic mouse model.

Dataset

identifier:	1784518
description:	epitope description:YEDRYYRE antigen name:Major prion protein host organism:Mus musculus antibody name:Sha31
aggregation:	instance of dataset
availability:	available
primaryPublications:	20436680

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019824
landingPage:	http://www.iedb.org/assay/1784518

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2010

Dimension

study type:	b cell assays
subject species:	Ovis aries

Person

fullName:	Thierry Baron Anna Bencsik Eric Morignat

Data Type

method:	western blot

Study

name:	Prions of ruminants show distinct splenotropisms in an ovine transgenic mouse model.
description:	The epitope specific mAb detected the PrP^res form of scrapie protein in the spleen and brain of the transgenic mouse model overexpressing the ovine PrP protein A136R154Q171 allele (TgOvPrP4) infected with brain extracts from cattle classical BSE but only in the brain of mice inoculated with L-type BSE and TME-in-cattle.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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