Development of a CENP-A/CENP-B-specific immune response in a patient with systemic sclerosis. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Development of a CENP-A/CENP-B-specific immune response in a patient with systemic sclerosis.

Dataset

identifier:	1784691
description:	epitope description:FIDEPRRRPI antigen name:Alanine--tRNA ligase, cytoplasmic host organism:Homo sapiens Caucasian
aggregation:	instance of dataset
availability:	available
primaryPublications:	12124871

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1004700
landingPage:	http://www.iedb.org/assay/1784691

Publication

type:	Literature
publicationVenue:	Arthritis Rheum
dates:	2002

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Michael Mahler Rudolf Mierau Ekkehard Genth Martin Blü thner

Data Type

method:	western blot

Study

name:	Development of a CENP-A/CENP-B-specific immune response in a patient with systemic sclerosis.
description:	The epitope was recognized by serum samples that were taken later during disease progression. The author stated that they observed what appeared to be epitope spreading, leading to a cross reactivity between the G-P-X1-R-X2 motif on CENP-A with the epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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