Evidence for specific polypeptide chain folding in myelin basic protein from reactions between fragments of the protein and monoclonal antibodies.

Title:

Evidence for specific polypeptide chain folding in myelin basic protein from reactions between fragments of the protein and monoclonal antibodies.

Dataset

identifier:	1784705
description:	epitope description:VVHFFKNIV antigen name:Myelin basic protein host organism:Mus musculus antibody name:18.25
aggregation:	instance of dataset
availability:	available
primaryPublications:	2426407

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1017956
landingPage:	http://www.iedb.org/assay/1784705

Publication

type:	Literature
publicationVenue:	J Neurochem
dates:	1986

Dimension

study type:	b cell assays
subject species:	Cavia porcellus

Person

fullName:	E C Alvord Jr S Hruby R E Martenson G E Deibler M J Law

Data Type

method:	antigen inhibition

Study

name:	Evidence for specific polypeptide chain folding in myelin basic protein from reactions between fragments of the protein and monoclonal antibodies.
description:	Binding of the epitope-specific mAb to guinea pig BP was inhibited by rabbit BP. The epitope sequence was deduced by study of truncated peptides. The specific conformation of this epitope, which includes probably the Lys-89 and possibly the Asn-90 and Val-92 side chains, could be formed by the association of sequence 84-92 with either sequence Ile-Leu-Asp-Ser-Ile-Gly-Arg-Phe-Phe (37-45) or with sequence Val-Leu-Ser-Arg-Phe (108-112) to form beta-sheet structures essentially identical with those that appear to be present in the intact BP.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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