PrP conformational transitions alter species preference of a PrP-specific antibody. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

PrP conformational transitions alter species preference of a PrP-specific antibody.

Dataset

identifier:	1784849
description:	epitope description:KTNMK antigen name:Major prion protein host organism:Mus musculus C57BL/6 antibody name:3F4
aggregation:	instance of dataset
availability:	available
primaryPublications:	20194495

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019822
landingPage:	http://www.iedb.org/assay/1784849

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2010

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Wen-Quan Zou Jan Langeveld Xiangzhu Xiao Shugui Chen Patrick L McGeer Jue Yuan Michael C Payne Hae-Eun Kang John McGeehan Man-Sun Sy Neil S Greenspan David Kaplan Gong-Xian Wang Piero Parchi Edward Hoover Geoff Kneale Glenn Telling Witold K Surewicz Qingzhong Kong Jian-Ping Guo

Data Type

method:	antigen inhibition (~ IC50)

Study

name:	PrP conformational transitions alter species preference of a PrP-specific antibody.
description:	This conserved sequence is also present in elk PrP. Binding of the epitope-specific mAb to human PrP was partially inhibited by the peptide in ELISA. Inhibition was also measured by western blot.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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