Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.

Title:

Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.

Dataset

identifier:	1785442
description:	epitope description:AGPKAQVEAIQKY antigen name:eukaryotic aspartyl protease host organism:Mus musculus BALB/c antibody name:2H12, 11F3, 9E10
aggregation:	instance of dataset
availability:	available
primaryPublications:	20367477

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1019826
landingPage:	http://www.iedb.org/assay/1785442

Publication

type:	Literature
publicationVenue:	J Infect Dis
dates:	2010

Dimension

study type:	b cell assays
subject species:	Necator americanus

Person

fullName:	Mark S Pearson Darren A Pickering Leon Tribolet Leanne Cooper Jason Mulvenna Luciana M Oliveira Jeffrey M Bethony Peter J Hotez Alex Loukas

Data Type

method:	biological activity

Study

name:	Neutralizing antibodies to the hookworm hemoglobinase Na-APR-1: implications for a multivalent vaccine against hookworm infection and schistosomiasis.
description:	The epitope specific monoclonal antibodies inhibited protease activity of Na-APR-1 in an in vitro protease assay.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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