Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1016255 |
| landingPage: |
http://www.iedb.org/assay/1785536 |
| type: |
Literature
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| publicationVenue: |
Proc Natl Acad Sci U S A
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| dates: |
1993
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| study type: | b cell assays |
| subject species: |
| fullName: |
Z M Sthoeger
E Mozes
B Tartakovsky
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| method: |
in vivo assay
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| name: |
Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation.
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| description: |
Four weeks after adoptive transfer of anti-cardiolipin mAb, a severe gestational failure with low pregnancy rates, low number of fetuses, and a high rate of resorptions was observed. Moreover, embryos obtained from the ACA-immunized females on day 3.5 of pregnancy were severely impaired, demonstrating developmental delay and abnormal morphology. These abnormal embryos failed also to develop in an in vitro implantation model. Furthermore, specifiic binding of themAb to the trophectoderm cell lineage of in vitro implanting normal embryos was observed.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
