Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.

Title:

Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.

identifier:	1785685
description:	epitope description:RYPNQVYYRPM antigen name:Major prion protein host organism:Mus musculus PrP null antibody name:BAR234
aggregation:	instance of dataset
availability:	available
primaryPublications:	15618225

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Cé cile Fé raudet Nathalie Morel Sté phanie Simon Hervé Volland Yveline Frobert Christophe Cré minon Didier Vilette Sylvain Lehmann Jacques Grassi

method:	biological activity

name:	Screening of 145 anti-PrP monoclonal antibodies for their capacity to inhibit PrPSc replication in infected cells.
description:	Incubation of mouse neuroblastoma N2a cells, chronically infected with 22L mouse-adapted scrapie strain, with epitope-specific mAbs which bind PrPc but not PrPSc leads to reduced total cellular levels of PrPSc.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.