Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS.

Title:

Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS.

Dataset

identifier:	1787210
description:	epitope description:cardiolipin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10949723

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020730
landingPage:	http://www.iedb.org/assay/1787210

Publication

type:	Literature
publicationVenue:	Clin Exp Rheumatol
dates:	2000

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Y Levy Y Sherer A Mathieu A Cauli G Passiu G Sanna Z Janackovic M Blank Y Shoenfeld

Data Type

method:	antigen inhibition

Study

name:	Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS.
description:	Cardiolipin in complex with beta-2-glycoprotein I was able to inhibit the binding of cardiolipin-affinity purified antibodies from binding to cardiolipin. Cardiolipin alone was not effective. Direct binding by ELISA was also shown.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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