Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS.

Title:

Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS.

Dataset

identifier:	1787239
description:	epitope description:cardiolipin host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	10949723

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020730
landingPage:	http://www.iedb.org/assay/1787239

Publication

type:	Literature
publicationVenue:	Clin Exp Rheumatol
dates:	2000

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Y Levy Y Sherer A Mathieu A Cauli G Passiu G Sanna Z Janackovic M Blank Y Shoenfeld

Data Type

method:	in vivo assay

Study

name:	Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS.
description:	Human affinity-purified antibodies were able to induce experiential anti-phospholipid syndrome in mice, with increased coagulation time, thrombocytopenia, and increased fetal resorptions. The murine antibodies also bound to cardiolipin complexed with beta 2 glycoprotein I.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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