Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen.

Dataset

identifier:	1785715
description:	epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group host organism:Mus musculus C57BL/6 GalNAc Transferase null
aggregation:	instance of dataset
availability:	available
primaryPublications:	12589143

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1020576
landingPage:	http://www.iedb.org/assay/1785715

Publication

type:	Literature
publicationVenue:	Transplantation
dates:	2003

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Muhammad M Mohiuddin Haruko Ogawa Deng-Ping Yin Jikun Shen Uri Galili

Data Type

method:	ELISA

Study

name:	Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen.
description:	a1,3GT KO Mice rejecting or accommodating syngeneic wild type heart transplants were injected with epitope specific memory anti-Gal B cells. Mice rejecting the transplant produced slightly higher levels of IgG as compared to the mice accommodating the cardiac graft. The isotypes of the IgG produced to the epitope were primarily IgG1, followed by IgG2b, IgG3, then IgG2a. The IgG2b subclass was associated with graft acceptance.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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