Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus.

Dataset

identifier:	1786028
description:	epitope description:SGRGKGGKGLGKGGAKRHRKVL + ACET(K8, K12, K16) antigen name:Histone H4 host organism:Mus musculus MLR/lpr
aggregation:	instance of dataset
availability:	available
primaryPublications:	17530637

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1005019
landingPage:	http://www.iedb.org/assay/1786028

Publication

type:	Literature
publicationVenue:	Arthritis Rheum
dates:	2007

Dimension

study type:	b cell assays
subject species:	Mus musculus

Person

fullName:	Jü rgen W Dieker Justin H Fransen Casandra C van Bavel Jean-Paul Briand Cor W Jacobs Sylviane Muller Jo H Berden Johan van der Vlag

Data Type

method:	in vivo assay

Study

name:	Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus.
description:	Mice immunized with the epitope developed worse SLE as measured by survival, proteinuria and skin lesions than non-immunized mice.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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