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Title: Opposite beta2-glycoprotein I requirement for the binding of infectious and autoimmune antiphospholipid antibodies to cardiolipin liposomes is associated with antibody avidity.
identifier: 1786480
description:
epitope description:cardiolipin
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 9889373
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1006099
landingPage: http://www.iedb.org/assay/1786480
type:
Literature
publicationVenue:
Biochim Biophys Acta
dates:
1999
study type: b cell assays
subject species: Bos taurus
fullName:
C M Celli
A E Gharavi
H Chaimovich
method:
ELISA
name:
Opposite beta2-glycoprotein I requirement for the binding of infectious and autoimmune antiphospholipid antibodies to cardiolipin liposomes is associated with antibody avidity.
description:
The patient sera bound the epitope in ELISA assay. Three sera bound the epitope with high avidity and seven sera bound the epitope with low avidity. Avidity was determined using NaCl in increasing concentrations in the ELISA assay. ß2-glycoprotein reduced sera binding to the epitope. Binding to the epitope in a vesicle was also measured in a carboxyfluorescein leaking assay.

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