Linear PADRE T helper epitope and carbohydrate B cell epitope conjugates induce specific high titer IgG antibody responses.

Title:

Linear PADRE T helper epitope and carbohydrate B cell epitope conjugates induce specific high titer IgG antibody responses.

identifier:	1786569
description:	epitope description:alpha-D-Galp-(1->2)-[alpha-D-Abep-(1->3)]-alpha-D-Manp-(1->4)-alpha-L-Rhap antigen name:lipopolysaccharide host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	10640784

study type:	b cell assays
subject species:	Salmonella typhimurium SH 4809

fullName:	J Alexander M F del Guercio A Maewal L Qiao J Fikes R W Chesnut J Paulson D R Bundle S DeFrees A Sette

method:	ELISA

name:	Linear PADRE T helper epitope and carbohydrate B cell epitope conjugates induce specific high titer IgG antibody responses.
description:	Non-natural pan HLA-DR epitope (PADRE) as a carrier induced Ab responses to the epitope. Predominantly IgG response was observed after one boost. Various tri- and tetra-glucoconjugates were used to define the optimal epitope. The substitution, deletion or modification of the Abe and Rha residues was particularly deleterious for the recognition.

name:	iedb
homePage:	http://www.iedb.org

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