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Title: Similarities and disparities between core-specific and O-side-chain-specific antilipopolysaccharide monoclonal antibodies in models of endotoxemia and bacteremia in mice.
identifier: 1789597
description:
epitope description:alpha-D-Glcp-(1->3)-[L-alpha-D-Hepp-(1->7)]-L-alpha-D-Hepp-4P
antigen name:lipopolysaccharide
host organism:Mus musculus NZB
aggregation:
instance of dataset
availability:
available
primaryPublications: 9009348
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1006113
landingPage: http://www.iedb.org/assay/1789597
type:
Literature
publicationVenue:
Infect Immun
dates:
1997
study type: b cell assays
subject species: Enterobacteriaceae
fullName:
S Bailat
D Heumann
D Le Roy
J D Baumgartner
E T Rietschel
M P Glauser
F Di Padova
method:
in vivo assay
name:
Similarities and disparities between core-specific and O-side-chain-specific antilipopolysaccharide monoclonal antibodies in models of endotoxemia and bacteremia in mice.
description:
The epitope was deduced in the reference, Muller-Loennies et al, J Biol Chem: 278(28) 2003 [PMID: 12716894].
The epitope specific monoclonal antibodies protected mice from challenge with LPS from E. coli O111. The humanized IgG1 antibody protected 8/8 mice and the original mouse IgG2a monoclonal antibody protected 7/8.

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