Antibodies against the VRT101 laminin epitope correlate with human SLE disease activity and can be removed by extracorporeal immunoadsorption.

Title:

Antibodies against the VRT101 laminin epitope correlate with human SLE disease activity and can be removed by extracorporeal immunoadsorption.

identifier:	1788915
description:	epitope description:KEGYKVRLDLNITLEFRTTSK antigen name:Laminin subunit alpha-1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	17686790

study type:	b cell assays
subject species:	Mus musculus

fullName:	H Amital M Heilweil-Harel R Ulmansky M Harlev E A Hershko Y Naparstek

method:	antigen inhibition

name:	Antibodies against the VRT101 laminin epitope correlate with human SLE disease activity and can be removed by extracorporeal immunoadsorption.
description:	The epitope sequence was published in the cited reference Amital et al., J Immunol. 2005 Oct 15 175(8):5516-23, [PMID: 16210660]. Immunoadsorption of SLE sera on an eptiope-conjugated sepharose column eliminated the reactivity of SLE sera with the epitope. Direct ELISAs showed that sera from 57% of the SLE patients showed positive reaction.

name:	iedb
homePage:	http://www.iedb.org

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