Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1006729 |
| landingPage: |
http://www.iedb.org/assay/1472943 |
| type: |
Literature
|
| publicationVenue: |
Virology
|
| dates: |
1995
|
| study type: | b cell assays |
| subject species: | Foot-and-mouth disease virus C-S8c1 |
| fullName: |
M G Mateu
J A Camarero
E Giralt
D Andreu
E Domingo
|
| method: |
in vivo assay
|
| name: |
Direct evaluation of the immunodominance of a major antigenic site of foot-and-mouth disease virus in a natural host.
|
| description: |
VP1, for which amino acid sequence positions are given in the paper, is processed from the larger polyprotein, the sequence of which appears in the database.
Sera from an animal vaccinated with a peptide including the A19 epitope gave a response against the epitope approximately equal to the response to virus. This implied that the immune response to this peptide was directed primarily to the A19 epitope. Sera from this animal either affinity purified against Protein A or against a slightly larger peptide including the A19 epitope (YTASARGDLAHLTTTHARHLPC) gave 100% inhibition in a neutralization assay. In addition, a viral variant, SD6-28, bearing a His to Arg mutation at position 11 within the epitope, was poorly neutralized by the affinity-purified antisera, indicating that this position is important for epitope reactivity.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
