Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis.

Title:

Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis.

Dataset

identifier:	1473023
description:	epitope description:TPAYYTKDTNNNLTLV antigen name:Major outer membrane protein P.IA host organism:Mus musculus BALB/c antibody name:Mouse sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	7543883

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1007414
landingPage:	http://www.iedb.org/assay/1473023

Publication

type:	Literature
publicationVenue:	Infect Immun
dates:	1995

Dimension

study type:	b cell assays
subject species:	Neisseria meningitidis serogroup B H44/76

Person

fullName:	P Hoogerhout E M Donders J A van Gaans-van den Brink B Kuipers H F Brugghe L M van Unen H A Timmermans G J ten Hove A P de Jong C C Peeters

Data Type

method:	ELISA

Study

name:	Conjugates of synthetic cyclic peptides elicit bactericidal antibodies against a conformational epitope on a class 1 outer membrane protein of Neisseria meningitidis.
description:	The epitope is cyclized. Amino acid positions differ because the database sequence includes the signal polypeptide. Antisera generated using both adjuvants responded well to whole bacteria. Examination of subclass responses by this assay indicated that the antibody elicited in all mice included subclasses IgG1, IgG2a, IgG2b, and IgG3.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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