Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus.

Title:

Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus.

identifier:	1473036
description:	epitope description:TTCTASARGDLAHPTTTHACHL host organism:Cavia porcellus Duncan-Hartley antibody name:Guinea pig sera
aggregation:	instance of dataset
availability:	available
primaryPublications:	15780448

study type:	b cell assays
subject species:

fullName:	Eliandre de Oliveira Miguel Angel Jimé nez-Clavero José Ignacio Nú ñ ez Francisco Sobrino David Andreu

method:	ELISA

name:	Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus.
description:	This peptide was derived as a consensus sequence of antigenic site A, corresponding to the GH loop of the FMDV VP1 protein residues 134-155. In order to circularize this peptide, Tyr136 and Arg153 were replaced with Cys residues. Guinea pigs vaccinated with the consensus epitope A22(147P) recognized the epitope in ELISA. Reactivity was low for animals immunized with a cyclic version of this epitope.

name:	iedb
homePage:	http://www.iedb.org

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