Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1007641 |
| landingPage: |
http://www.iedb.org/assay/1474414 |
| type: |
Literature
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| publicationVenue: |
PLoS One
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| dates: |
2007
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| study type: | b cell assays |
| subject species: |
| fullName: |
Shinji L Okitsu
Olivier Silvie
Nicole Westerfeld
Marija Curcic
Andreas R Kammer
Markus S Mueller
Robert W Sauerwein
John A Robinson
Blaise Genton
Dominique Mazier
Rinaldo Zurbriggen
Gerd Pluschke
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| method: |
immuno staining
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| name: |
A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial.
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| description: |
The authors synthesized a cyclic mimotopic peptide based on the NPNA-repeat region of CSP from P. falciparum. The peptides folded conformation comes from cross-linking of an amino group at the beta position of Pro at position 6 to the spatially adjacent side-chain carboxyl of Glu, which replaces Ala at position 16. This peptide was designed to optimize both synthesis and immunogenicity.
After three immunizations, all volunteers inoculated with the immunopotentiating reconstituted influenza virosome (IRIV) PEV302 containing the UK-39 epitope showed a vaccine-induced increase in P. falciparum-specific titers in IFA and Western blot analysis for UK-39 at the 10ug concentration and UK-39 plus AMA49-C1 at the 50ug concentration. When administered at eh 50ug concentration, UK-39 alone induced responses in 5 of 7 volunteers. Formulating the vaccine with another peptide, AMA49-C1, did not negatively affect immunogenicity.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
