The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope.

Title:

The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope.

Dataset

identifier:	1476785
description:	epitope description:LVRSDYKFYEDANGTRDHKKGRHT antigen name:Outer membrane protein A (3aII*Gd) host organism:Chinchilla lanigera antibody name:Chinchilla middle ear fluid
aggregation:	instance of dataset
availability:	available
primaryPublications:	12902501

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006363
landingPage:	http://www.iedb.org/assay/1476785

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2003

Dimension

study type:	b cell assays
subject species:	Haemophilus influenzae NTHi 1128

Person

fullName:	Laura A Novotny Lauren O Bakaletz

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope.
description:	The epitope sequence is provided in Novotny et al. (2000) [PMID:10722609]. Middle ear fluids from six of seven experimentally infected chinchillas had moderate to high reactivity to this peptide in an SPR assay. In one reactive chinchilla in which the results from both ears were presented, the fluid from the right ear had only weak reactivity to the epitope compared to high reactivity from left ear fluid.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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