The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus.

Title:

The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus.

identifier:	1477813
description:	epitope description:GPRLQPY antigen name:Spike glycoprotein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	18067984

study type:	b cell assays
subject species:	Porcine epidemic diarrhea virus

fullName:	Deu John M Cruz Chul-Joong Kim Hyun-Jin Shin

method:	ELISA

name:	The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus.
description:	Mice immunized with the S-CT24 peptide (ACFSGCCRGPRLQPYEAFQKVHVQ) containing the GPRLQPY epitope motif showed strong reactivity to the epitope containing peptide, and intermediate reactivity to the whole virus. By contrast, immunization with the same peptide S-CT-27 (ACFSGCCREAFQKVHVQ) minus this motif failed to show reactivity against the whole virus or the S-CT24 peptide. The authors thus deduced the GPRLQPY motif found in the C-terminal region of the spike protein as the antigenic site.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.