Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes.

Title:

Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes.

identifier:	1477830
description:	epitope description:G304, E383, P384 antigen name:Genome polyprotein host organism:Mus musculus antibody name:3H5-1, M8051122, 9F16, 9F11, 2Q1899
aggregation:	instance of dataset
availability:	available
primaryPublications:	17881453

study type:	b cell assays
subject species:	Dengue virus 2 Thailand/16681/84

fullName:	Soila Sukupolvi-Petty S Kyle Austin Whitney E Purtha Theodore Oliphant Grant E Nybakken Jacob J Schlesinger John T Roehrig Gregory D Gromowski Alan D Barrett Daved H Fremont Michael S Diamond

method:	flow cytometry

name:	Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes.
description:	The anti-DENV-2 mAbs, which contact the epitopic residues, are type-specific as shown by their strong binding to DENV-2-infected Raji cells, but lack of binding to DENV-1-, DENV-3- , or DENV-4-infected cells.

name:	iedb
homePage:	http://www.iedb.org

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