Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.

Title:

Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.

Dataset

identifier:	1477897
description:	epitope description:D568, R656 antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:18A7.4
aggregation:	instance of dataset
availability:	available
primaryPublications:	7707508

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006632
landingPage:	http://www.iedb.org/assay/1477897

Publication

type:	Literature
publicationVenue:	J Virol
dates:	1995

Dimension

study type:	b cell assays
subject species:	Feline infectious peritonitis virus (strain 79-1146)

Person

fullName:	W V Corapi R J Darteil J C Audonnet G E Chappuis

Data Type

method:	biological activity

Study

name:	Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.
description:	Monoclonal antibody 18A7.4 neutralized FIPV infection of CRFK cells but did not neutralize an escape mutant containing mutations D568V and R656K in the spike protein, indicating that one or both of these are residues involved in recognition.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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