Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.

Title:

Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.

Dataset

identifier:	1477899
description:	epitope description:D643 antigen name:Spike glycoprotein host organism:Mus musculus BALB/c antibody name:24H5.4
aggregation:	instance of dataset
availability:	available
primaryPublications:	7707508

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1006632
landingPage:	http://www.iedb.org/assay/1477899

Publication

type:	Literature
publicationVenue:	J Virol
dates:	1995

Dimension

study type:	b cell assays
subject species:	Feline infectious peritonitis virus (strain 79-1146)

Person

fullName:	W V Corapi R J Darteil J C Audonnet G E Chappuis

Data Type

method:	biological activity

Study

name:	Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement.
description:	Monoclonal antibody 24H5.4 neutralized FIPV infection of CRFK cells but did not neutralize an escape mutant containing the mutation D643Y in the spike protein, indicating that this is a residue involved in recognition.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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