Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes.

Title:

Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes.

identifier:	1477902
description:	epitope description:G304, K305, K307, K310 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:1A1D-2
aggregation:	instance of dataset
availability:	available
primaryPublications:	17881453

study type:	b cell assays
subject species:	Dengue virus 2 Thailand/16681/84

fullName:	Soila Sukupolvi-Petty S Kyle Austin Whitney E Purtha Theodore Oliphant Grant E Nybakken Jacob J Schlesinger John T Roehrig Gregory D Gromowski Alan D Barrett Daved H Fremont Michael S Diamond

method:	flow cytometry

name:	Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes.
description:	The contact residues of anti-DENV2 subcomplex-specific neutralizing mAb were mapped using yeast-displayed point mutations of Domain III (DIII) of the E protein. The epitope was mapped to a region flanking the lateral ridge of DIII bound by type-specific neutralizing mAbs.

name:	iedb
homePage:	http://www.iedb.org

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