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Title: Vaccines prepared from chimeras of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies and protective immunity to multiple serotypes of FMDV.
identifier: 1477991
description:
epitope description:T678, T681
antigen name:Genome polyprotein
host organism:Mus musculus BALB/c
antibody name:2PD11
aggregation:
instance of dataset
availability:
available
primaryPublications: 7523697
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1006414
landingPage: http://www.iedb.org/assay/1477991
type:
Literature
publicationVenue:
J Virol
dates:
1994
study type: b cell assays
subject species: Foot-and-mouth disease virus (strain A12)
fullName:
E Rieder
B Baxt
J Lubroth
P W Mason
method:
biological activity
name:
Vaccines prepared from chimeras of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies and protective immunity to multiple serotypes of FMDV.
description:
The epitope is described by Baxt et al. (1989) J. Virol. 63:2143 [PMID: 2467993]. Numbers differ because the paper uses numbering from the mature VP3 protein which is processed from the larger polyprotein that is found in the database.
Epitope-specific mAb reactive with an epitope in VP3 of A12 FMDV neutralized the activity of A12 virus in vitro. When amino acids 131-157 from the G-H loop of VP1 protein of strain A12 (NGTNKYSASGSGVRGDFGSLAPRVARQ) were replaced with amino acids from the G-H loop of strain O1 BFS (NGECRYSRNAVPNLRGDLQYLAQKVART) or strain C3 Resende (TGTTTYTTSARRGDLAHLATAHARH), reactivity to this VP3 epitope remained unaffected.

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