A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C.

Title:

A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C.

identifier:	1478143
description:	epitope description:ASARGDLAHLTTTHARHLP antigen name:Polyprotein host organism:Mus musculus BALB/c antibody name:7FC12, 7AH1, 7EE6
aggregation:	instance of dataset
availability:	available
primaryPublications:	1690261

study type:	b cell assays
subject species:	Foot-and-mouth disease virus C-S8c1

fullName:	M G Mateu M A Martí nez L Capucci D Andreu E Giralt F Sobrino E Brocchi E Domingo

method:	biological activity

name:	A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C.
description:	The positions of the epitope identified in the paper refer to the mature VP1 protein, which is processed from the polyprotein whose numbering is used in the database accession sequence. Epitope-specific monoclonal antibody 7FC12 (and closely related mAbs 7AH1 and 7EE6) were raised against C₃ Indaial and were able to neutralize homologous virus in vitro. 7FC12 is IgG1, 7EE6 is IgG3, the isotype of 7AH1 was not determined.

name:	iedb
homePage:	http://www.iedb.org

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